The scientists who built the platform, with founder-led execution

Alexey Kovalev, MD, PhD

Co-Founder & Chief Scientific Officer

Alexey Vyacheslavovich Kovalev is a medical scientist specializing in regenerative medicine and tissue engineering, and the scientific architect of Regentron’s in-vivo bioreactor systems, biocomposite cell-aggregate engineering, and minimally invasive delivery capabilities. He remains actively engaged in research and clinical practice across bone, cartilage, and ocular repair. He graduated from Ivanovo State Medical Institute in 1993, completed postgraduate training in Histology, Cytology and Cell Biology in 1996, and in 1997 earned the degree of Candidate of Medical Sciences — the Russian doctoral degree equivalent to a PhD — for experimental research on skin-wound healing. His early career included academic research and leadership of a licensed stem-cell laboratory in Moscow. He also holds specialist qualifications in surgery and ophthalmology.

Kovalev’s work covers cellular technologies, tissue regeneration, bioartificial organs, medical bioreactors, cellular spheroids, and bioprinting. He is the originator of four registered scientific directions, which continue to define Regentron’s research programme, spanning the restoration of injured organs inside in-vivo bioreactors with controlled nutrient media; tissue-engineering bioreactors using aerosol delivery of culture nutrient media; bone-marrow cell transplantation to support regeneration of the retina and optic nerve; and tissue-engineered skeletogenic membranes. His broader research includes bone, cartilage, skin, spinal-cord, and ocular repair.

Kovalev is the author and co-author of more than 150 scientific publications appearing in journals such as Tissue Engineering Part A, Acta Biomaterialia, ACS Omega, International Journal of Molecular Sciences, Journal of Bone Oncology, International Journal of Bioprinting, and Biomedical Optics Express. He holds 57 patents for inventions, with further filings in preparation.

Vladimir Mironov, MD, PhD

Scientific Advisor

Professor Vladimir Mironov, MD, is a bioengineer, physician-scientist, and one of the pioneers of bioprinting. He earned his medical degree from Ivanovo State Medical Institute in 1977 and qualified as a Candidate of Medical Sciences at the Second Moscow Pirogov Medical Institute in 1980. His international career included research training in Germany and appointments in regenerative medicine and tissue biofabrication at the Medical University of South Carolina, followed by research work in Brazil.

Mironov helped establish the conceptual foundations of organ printing. He co-authored the landmark 2003 paper Organ Printing: Computer-Aided Jet-Based 3D Tissue Engineering, advanced scaffold-free bioprinting based on self-assembling tissue spheroids, and contributed to the development of the Fabion bioprinter. As a leading investigator, he helped produce the first reported functional and vascularized organ construct created through bioprinting—a mouse thyroid-gland construct. (Trends in Biotechnology, PubMed)

His later research includes magnetic-levitational bioassembly, viable human cartilage constructs assembled under microgravity aboard the International Space Station, vascularized organ construction, tissue spheroids, in-situ biofabrication, and space biomedicine. He serves on the Strategic Advisory Board of the International Society for Biofabrication and received the Society’s Senior Investigator Award in 2018. (ISBF Strategic Advisory Board, Science Advances, ISBF Award)